Non-Random Pattern of Integration for Epstein-Barr Virus with Preference for Gene-Poor Genomic Chromosomal Regions into the Genome of Burkitt Lymphoma Cell Lines
Background: Epstein-Barr virus (EBV) is an oncogenic virus found in about 95% of endemic Burkitt lymphoma (BL) cases.In latently infected cells, EBV DNA is mostly maintained in episomal Bandages form, but it can also be integrated into the host genome, or both forms can coexist in the infected cells.Methods: In this study, we mapped the chromosomal